Fiber-reinforced hydrogel scaffolds for heart valve tissue engineering.
Identifieur interne : 002D96 ( Main/Exploration ); précédent : 002D95; suivant : 002D97Fiber-reinforced hydrogel scaffolds for heart valve tissue engineering.
Auteurs : Maryam Eslami [États-Unis] ; Nihal Engin Vrana [États-Unis] ; Pinar Zorlutuna [États-Unis] ; Shilpa Sant [États-Unis] ; Sungmi Jung [États-Unis] ; Nafiseh Masoumi [États-Unis] ; Ramazan Ali Khavari-Nejad [Iran] ; Gholamreza Javadi [Iran] ; Ali Khademhosseini [États-Unis]Source :
- Journal of biomaterials applications [ 1530-8022 ] ; 2014.
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English descriptors
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Abstract
Heart valve-related disorders are among the major causes of death worldwide. Although prosthetic valves are widely used to treat this pathology, current prosthetic grafts cannot grow with the patient while maintaining normal valve mechanical and hemodynamic properties. Tissue engineering may provide a possible solution to this issue through using biodegradable scaffolds and patients' own cells. Despite their similarity to heart valve tissue, most hydrogel scaffolds are not mechanically suitable for the dynamic stresses of the heart valve microenvironment. In this study, we integrated electrospun poly(glycerol sebacate) (PGS)-poly(ɛ-caprolactone) (PCL) microfiber scaffolds, which possess enhanced mechanical properties for heart valve engineering, within a hybrid hydrogel made from methacrylated hyaluronic acid and methacrylated gelatin. Sheep mitral valvular interstitial cells were encapsulated in the hydrogel and evaluated in hydrogel-only, PGS-PCL scaffold-only, and composite scaffold conditions. Although the cellular viability and metabolic activity were similar among all scaffold types, the presence of the hydrogel improved the three-dimensional distribution of mitral valvular interstitial cells. As seen by similar values in both the Young's modulus and the ultimate tensile strength between the PGS-PCL scaffolds and the composites, microfibrous scaffolds preserved their mechanical properties in the presence of the hydrogels. Compared to electrospun or hydrogel scaffolds alone, this combined system may provide a more suitable three-dimensional structure for generating scaffolds for heart valve tissue engineering.
DOI: 10.1177/0885328214530589
PubMed: 24733776
Affiliations:
- Iran, États-Unis
- Connecticut, Massachusetts, Pennsylvanie
- Cambridge (Massachusetts), University Park (Pennsylvanie)
- Université Harvard, Université d'État de Pennsylvanie
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Le document en format XML
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Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran alik@rics.bwh.harvard.edu maryam.eslami2010@gmail.com maryam.eslami2010@srbiau.ac.ir.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Department of Biology, Islamic Azad University, Science and Research Branch, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Vrana, Nihal Engin" sort="Vrana, Nihal Engin" uniqKey="Vrana N" first="Nihal Engin" 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Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Biomedical Engineering Program and Mechanical Engineering Department, University of Connecticut, Storrs, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Biomedical Engineering Program and Mechanical Engineering Department, University of Connecticut, Storrs, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Sant, Shilpa" sort="Sant, Shilpa" uniqKey="Sant S" first="Shilpa" last="Sant">Shilpa Sant</name><affiliation wicri:level="4"><nlm:affiliation>Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA Department of Pharmaceutical Sciences University of Pittsburgh, School of Pharmacy, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA Department of Pharmaceutical Sciences University of Pittsburgh, School of Pharmacy, Pittsburgh, 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of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Department of Bioengineering, Pennsylvania State University, University Park, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Department of Bioengineering, Pennsylvania State University, University Park, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation></author><author><name sortKey="Khavari Nejad, Ramazan Ali" sort="Khavari Nejad, Ramazan Ali" uniqKey="Khavari Nejad R" first="Ramazan Ali" last="Khavari-Nejad">Ramazan Ali Khavari-Nejad</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Biology, Islamic Azad University, Science and Research Branch, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Javadi, Gholamreza" sort="Javadi, Gholamreza" uniqKey="Javadi G" first="Gholamreza" last="Javadi">Gholamreza Javadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Biology, Islamic Azad University, Science and Research Branch, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Khademhosseini, Ali" sort="Khademhosseini, Ali" uniqKey="Khademhosseini A" first="Ali" last="Khademhosseini">Ali Khademhosseini</name><affiliation wicri:level="4"><nlm:affiliation>Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA alik@rics.bwh.harvard.edu maryam.eslami2010@gmail.com maryam.eslami2010@srbiau.ac.ir.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Cambridge (Massachusetts)</settlement></placeName><orgName type="university">Université Harvard</orgName></affiliation></author></analytic><series><title level="j">Journal of biomaterials applications</title><idno type="eISSN">1530-8022</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Heart Valves</term><term>Hydrogels</term><term>Microscopy, Electron, Scanning</term><term>Sheep</term><term>Tissue Engineering</term><term>Tissue Scaffolds</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Hydrogels</term><term>Ingénierie tissulaire</term><term>Microscopie électronique à balayage</term><term>Ovis</term><term>Structures d'échafaudage tissulaires</term><term>Valves cardiaques</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Hydrogels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Heart Valves</term><term>Microscopy, Electron, Scanning</term><term>Sheep</term><term>Tissue Engineering</term><term>Tissue Scaffolds</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Hydrogels</term><term>Ingénierie tissulaire</term><term>Microscopie électronique à balayage</term><term>Ovis</term><term>Structures d'échafaudage tissulaires</term><term>Valves cardiaques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Heart valve-related disorders are among the major causes of death worldwide. Although prosthetic valves are widely used to treat this pathology, current prosthetic grafts cannot grow with the patient while maintaining normal valve mechanical and hemodynamic properties. Tissue engineering may provide a possible solution to this issue through using biodegradable scaffolds and patients' own cells. Despite their similarity to heart valve tissue, most hydrogel scaffolds are not mechanically suitable for the dynamic stresses of the heart valve microenvironment. In this study, we integrated electrospun poly(glycerol sebacate) (PGS)-poly(ɛ-caprolactone) (PCL) microfiber scaffolds, which possess enhanced mechanical properties for heart valve engineering, within a hybrid hydrogel made from methacrylated hyaluronic acid and methacrylated gelatin. Sheep mitral valvular interstitial cells were encapsulated in the hydrogel and evaluated in hydrogel-only, PGS-PCL scaffold-only, and composite scaffold conditions. Although the cellular viability and metabolic activity were similar among all scaffold types, the presence of the hydrogel improved the three-dimensional distribution of mitral valvular interstitial cells. As seen by similar values in both the Young's modulus and the ultimate tensile strength between the PGS-PCL scaffolds and the composites, microfibrous scaffolds preserved their mechanical properties in the presence of the hydrogels. Compared to electrospun or hydrogel scaffolds alone, this combined system may provide a more suitable three-dimensional structure for generating scaffolds for heart valve tissue engineering.</div></front></TEI><affiliations><list><country><li>Iran</li><li>États-Unis</li></country><region><li>Connecticut</li><li>Massachusetts</li><li>Pennsylvanie</li></region><settlement><li>Cambridge (Massachusetts)</li><li>University Park (Pennsylvanie)</li></settlement><orgName><li>Université Harvard</li><li>Université d'État de Pennsylvanie</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Eslami, Maryam" sort="Eslami, Maryam" uniqKey="Eslami M" first="Maryam" last="Eslami">Maryam Eslami</name></noRegion><name sortKey="Jung, Sungmi" sort="Jung, Sungmi" uniqKey="Jung S" first="Sungmi" last="Jung">Sungmi Jung</name><name sortKey="Khademhosseini, Ali" sort="Khademhosseini, Ali" uniqKey="Khademhosseini A" first="Ali" last="Khademhosseini">Ali Khademhosseini</name><name sortKey="Masoumi, Nafiseh" sort="Masoumi, Nafiseh" uniqKey="Masoumi N" first="Nafiseh" last="Masoumi">Nafiseh Masoumi</name><name sortKey="Sant, Shilpa" sort="Sant, Shilpa" uniqKey="Sant S" first="Shilpa" last="Sant">Shilpa Sant</name><name sortKey="Vrana, Nihal Engin" sort="Vrana, Nihal Engin" uniqKey="Vrana N" first="Nihal Engin" last="Vrana">Nihal Engin Vrana</name><name sortKey="Zorlutuna, Pinar" sort="Zorlutuna, Pinar" uniqKey="Zorlutuna P" first="Pinar" last="Zorlutuna">Pinar Zorlutuna</name></country><country name="Iran"><noRegion><name sortKey="Khavari Nejad, Ramazan Ali" sort="Khavari Nejad, Ramazan Ali" uniqKey="Khavari Nejad R" first="Ramazan Ali" last="Khavari-Nejad">Ramazan Ali Khavari-Nejad</name></noRegion><name sortKey="Javadi, Gholamreza" sort="Javadi, Gholamreza" uniqKey="Javadi G" first="Gholamreza" last="Javadi">Gholamreza Javadi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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